With good tinkering skills you'd be well advised to pay a gunsmith to do this for you.
On the face of it it's a simple screw-in swap if the new barrel is threaded to the size of the old, But the ejector rod cuts if any, the ejector rod keeper (for lack of a better word on the tip of my tongue), the barrel cone, the cylinder end gap, and the sight require specialized skills along with special tools. It's precision work and it is very easy to do incorrectly.