I also reload in a spare bedroom, which doubles as our office. There are two solid-core doors on 4x4 legs w/ shelves under, on opposite sides of the room. One is used for the computer stuff and the other is "general purpose", which includes having a press bolted to one end most of the time.
Having the computer in the same room is kind of handy, as I can read/enter reloading data in a spreadsheet as I'm making progress, rather than having to write it down and take it to the computer to transcribe it. The fact that it is 180° opposite means it can't be a distraction while actually running the press.
I haven't had enough spilled powder for it to be an issue in a carpeted room, but I did locate the tumbler and trimming operations in the garage.
I also open the door to run the media separator and I wear disposable gloves until I get the clean brass bagged. And the tumbler is noisy enough that nobody wants to listen to it.
Trimming isn't a health hazard, but I have a motorized one so it is rather noisy as well.
So,
Quiet and no health hazards = spare bedroom
Noisy and no health issues = garage
Health issues (lead compound dust) = outdoors