I'll be honest, I've not seen nor heard anything about RL22's temperature resistance. Based on the chart in the link above it appears to be one of the more sensitive powders. But according on what I've read the cartridge it is used in matters too. In 308 RL15 is supposed to be pretty stable, but in another cartridge may be more sensitive. It is listed as one of the more sensitive powders in that link, but it doesn't say what cartridge they tested it in.
According to the above link RL22 will lose about 1.7 fps for each degree temperature changes. Compared to H4350 which will lose less than .5 fps. All things being equal I'd take the more stable powder, but all things are rarely equal. I prefer H4350 for that reason and I get the accuracy and speed I want. But right now we've got to use the powder we have and if you're getting the accuracy and speed you want with RL22 then that is what I'd use.
If you develop a load at 70 degrees and shoot it at 0 you'd be looking at about 120 fps less speed. At "normal" hunting ranges that won't be a deal killer. Especially if you re-zero the rifle for those temperatures.