As mentioned above range is going to be the determining factor. I happen to be in my "rifled shotgun" stage of my early senior citizen crisis. I have acquired a couple of rifled barrels for some of the guns in my miliatry/tactical collection, and acquired an H&R 12 gauge Ultra Hunter-a 12 gauge rifled barrel built out of a 10 gauge barrel, a Mossy bolt rifled gun, and what I consider the most accurate rifled SG a Browning A Bolt(also just about the most expensive SG I have ever bought). I n addition I have tried the rifled screw in "chokes" and a cheap H&R 12 rifled barrel.
I believe that if you use a rifled barrel, and find sabot ammo that it "likes", and have a decent set of sights or a low X scope or red dot, you will be good to go at anywhere up to 100 yards, or maybe a little further. Use the Browning Bolt gun, a properly bedded Mossberg Bolt gun, or the H&R Ultra and you can do minute of felon out to 200 yards, and make most anyone uncomfortable at 250-300. Not recommending the real long ranges, but I have seen some amazing stuff when the right barrel is mated to the right ammo-that seems to be more important than anything and it will require experimentation.
My A Bolt seems to have fallen in love with the new Winchester copper sabots, and I would feel quite safe in claiming the real estate out to 225 yards with it. The next best rifled gun I have is a beater 870 old police gun that I put a used rifled barrel with an extension on, it delivers Federal premium sabots just short of the Browning, and it cost a total of $285 including the 3X scope (an old Weaver I had lying around). Go figure.........
If you are going to stay under 100-125 yards some experimenting with a good rifled barrel and different ammo should do you fine. Much further out and I would be putting my 30-30 barrel on my cheap H&R.
I think that you will find that slug hunting is great fun, and most anything hit by a sabot slug(about 50 caliber remember) isn't going anywhere far away.