The problems I've found include the following (number of incidents - i.e. number of different guns I found with the same problem - are in parentheses after each incident):
Wood stock poorly fitted to receiver/barrel (2);
Synthetic stock ditto (1);
Very heavy trigger, mushy, gritty and almost unusably bad (3);
Sights mis-aligned (2);
Chamber not bored fully "round" - more like an oval shape (1);
Rifling not cut properly, with a lot of "frosting" and jagged edges (1);
Butt-plate not aligned properly, screwed on crooked (1).
I know that older 10/22's didn't exhibit these sorts of problems much, and if you find an older rifle in stock somewhere, that's great (Wal-Mart often has older stock, as they'll take in 10 at a time and wait for these to sell before ordering more). However, based on what I've seen, I'm no longer recommending 10/22's - and I'm sad about this, as they were at one time probably the premier small semi-auto .22 rifle out there.