I had a P345. I've expressed my problems with it ad nausea on the Ruger forum to the point that people accused me of being anti-Ruger. Just for the record, I bought a Ruger over anything else because of the volume of their wheelguns I've owned and because of a propaganda/Article by a famous big bore sixgun writer who endorsed it.
First and foremost:
Pros-
Accuracy: My P345 was super accurate. Like a flippin' laser. Gosh!!! At combat ranges of 1-15 meters I did the old "one ragged hole" thing with it.
Comfortability: Very comfy for my big mitts. I got no hammer bite. I got no problems at all in that department.
Looks: I got the blued slide model with the Picca-whosits rail. I intended to keep it as a house gun and then wound up using as a carry weapon. It was just a great looking weapon. Shame, really.
(and now, the sour grapes)
Cons-
Slam shuts: that's right. If you vigorously drove a mag home, it would just go ahead and charge itself. This was caused by the slide lock lever being out of tolerance from the factory. It bothered me to no end. I don't want a weapon doing things I don't tell it to do.
FTF, FTE, stovepiping, etc.: yep. the gremlins of the brasspuker set.
I was nearly willing to put up with it and do the whole back and forth through the mail fandango with Ruger, until I needed it to function when my life was at stake. Then, I pretty much crossed it off of my list of firearms and relegated it to the same status as a 1911 Auto Ordnance (pre-Kahr), which means Paperweight ( I have one sitting beside my Apple ibook right now as I type that is holding down papers- something I never do with a wheelgun). A friend got interested in the Ruger, and I now have a Dan Wesson 357, and it's the only gun I ever lost money on. And, I will never ever buy another Ruger product again. That gun was just an example of sloppy workmanship and a poor work ethic. Ruger knew they had a problem, but they shipped them anyway. And, it nearly cost me my life for them to make a couple hundred bucks off of me.
My brasspuker chores are now handled by CZ. And, I'm a happy customer.
So, there ya have it. The meat of my experience with my Ruger P345. I will, for the rest of my life, warn people away from them.