Unique is the best overall powder in the 45 LC that I have used. I use "standard" pressure rounds even though I do have a Ruger Blackhawk, I am not interested in creating magnum level pressures or velocities in my light weight pistols. Hodgdon H110/W296 works well in my 357 Magnums and with full power loads in the 44 Magnum, but, in an N frame S&W, if you don't push the pressures up, I would not use it. I would not use high pressure loads in a N frame S&W as I don't want the recoil, and I don't want to batter the revolver.
I have used 2400 with 250/255 grain bullets. The 2400 load is the most powerful I have shot in my 45LC, accurate, powerful, uncomfortable. I don't recommend high doses of it, and I guess this would be the most powerful load you could shoot in the N frame.
M625-9 Mountain Gun 4" Barrel
250 JHP 8.5 grs Unique thrown, W-W cases, WLP primers
18-Mar-07 T = 55 °F V, accurate
Ave Vel = 830
Std Dev = 30
ES= 103.5
High= 893.4
Low= 789.8
Number Shots= 12
250 Nosler JHP 17.5 grs 2400 thrown, Master cases, Fed150 primers
18-Mar-07 T = 55 °F V, accurate uncomfortable recoil
Ave Vel = 971
Std Dev = 25
ES= 69.47
High= 1003
Low= 933.5
Number Shots= 11
255 LSWC (.452") 8.0 grs Unique thrown, lot 6/21/1993Starline cases, WLP primers
25-Mar-07 T = 80 °F accurate
Ave Vel = 800
Std Dev = 30
ES 99.02
High 847.2
Low 748.1
Number Shots 11
250 LRN (.452") Valiant 8.0 grs Unique lot 6/21/1993 thrown, R-P cases, WLP primers
25-Mar 07 T = 80°F accurate
Ave Vel = 814
Std Dev = 24
ES 72.81
High 847
Low 774.2
Number Shots 11
250 LRN (.454") Valiant 8.5 grs Unique thrown lot 5471, 4/3/06, R-P cases, WLP primers
25-Mar-07 T = 80 °F accurate
Ave Vel = 891
Std Dev = 17
ES 61.31
High 921.1
Low 859.8
Number Shots 27
255 LSWC (.452") 8.0 grs Unique lot 6/21/1993 mixed cases WLP (nickel)
23-Sep-07 T = 82 °F
Ave Vel = 802.5
Std Dev = 31.03
ES = 123.5
High = 867.2
Low = 743.6
N = 12
250 LSWC (.452") 10.5 grs AA#5 lot 12599 mixed cases WLP (nickel)
23-Sep-07 T = 82 °F
Ave Vel = 875.1
Std Dev = 19.36
ES = 62.64
High = 905.7
Low = 843
N = 12
250 LSWC (.452") 10.5 grs AA#5 lot 12599 mixed cases Wolf NCLP
23-Sep-07 T = 82 °F
Ave Vel = 826.2
Std Dev = 20.14
ES = 63.38
High = 862.1
Low = 798.7
N = 12