I personally think the 4506 is one of the better pistols ever produced by S&W.
Pros they tend to be accurate, very reliable and easy to shoot.
Cons they are large heavy handguns that require good to outstanding belts and good leather for comfortable carry.
If you are looking for a large accurate auto I don't think you will go wrong with the 4506.
Some people really don't like the traditional double action trigger, but it is what I learned on so it really does not bother me.
Charles