If you are thinking about shooting 410 out of it, do read up on the subjuct.
http://www.theboxotruth.com/docs/bot41.htm. 45 colt or 45 ACP would be better choices. As far as I'm concerned, S&W released the governor as a "Me too" entry into a niche market created by Taurus. Even giving it an uncharactoristicly S&W name to make it seem more like the Judge. It has its uses, but if you are looking to do some serious business, you might find there are better choices for this purpose. If you just want one then get one. No need to try to justify a legitimate use for it
I pretty much agree, but just to say, the Judge was out-selling everything on the market with a rotating cylinder, not sure recent sales figures. So, if it's a niche market, it's a huge niche and S&W couldn't really stand aside and let Taurus have a huge market without competition, could it?
I kinda like the light weight UL Judge Personal Defense, wouldn't want one of the heavier versions. I don't really want one at all, tell ya the truth, but if I did get one, it'd be a light, compact model. It'd make a good hiking gun if you have snakes like are in south Texas. A Personal Defense could be belt carried effectively, but then, I prefer my old Taurus 3" 66 .357 magnum for such duties.
I have a .410/.45 colt barrel for my TC Contender. Kinda useless, but it's also kinda fun.
If I was going to get a big/heavy Governor/Judge, a Raging Judge (.454 Carull) might be kinda cool. But, heck, I wouldn't really use it for anything. Others might, though, in bear country or as a survival weapon. I read somewhere they're coming with a screw on choke that stops the rotation of the shot column. That helps my TC get 20-25 yard patterns effective enough for birds and small game. Without it, the "pattern" doesn't exist beyond a few feet from what I've read and I can believe it.
If .45ACP is important to you, the Governor is the choice.
The OP is talking about home defense. I suppose the .410 buck shot could have merit for those living in thin walled apartments, but out here in the sticks, I'll keep my 20 gauge coach gun and other handgun options. No neighbors anywhere close.