I have used the Nyclads with a great deal of satisfaction in snubs for almost 30 years (and still do in a 1st year Colt Cobra and a S&W M67), BUT while wringing out my new S&W 642 I found that Hornady Critical Defense 110 gr +P shot closer to point of aim and in a tighter group than anything else, including the Nyclads and Gold Dots. You may want to take a sampling of each of the recommended loads to the range and see which your revolver prefers. Word of warning, the recoil is sharp but not unbearable in the 642 Airweight.
Probably won't impress the benchrest crowd with fist-sized groups at 10 yards, but I'm content.