Rimfire revolvers need a really good whack from the firing pin. After the first cylinder full, when loading you are pushing bore diameter bullets into a fouled bore diameter chamber. Chances are good that the firing pin blow has to push the whole round forward a bit before the rim starts to crush. Of course, the double action pull hammer fall is shorter and weaker than the single action.
Centerfire guns can be touchy, too. I have a Smith Model 66 that I have fired hundreds of rounds of .357 factory loads and handloads through without a hint of trouble. I made up a big batch of light lead bullet loads in .38 Special cases for my M10, which shoots them nicely, and tried them in the 66. Misfires every cylinder full firing double action. Maybe the rim is a scooch thinner, or something.