To start, my only experience with Colt revolvers is with new production Pythons and Anacondas so I can add nothing on Colt revolvers.
In 22RF, I have Model 17s with a 6" barrel and 8-3/8" barrel and a Model 18 with a 4" barrel.They are accurate and I like them, but I'm am S&W fan.
I also have a Ruger Single Six convertible. While I have a few Ruger Blackhawk centerfire guns, I'm not a big fan of them. But the 22RF Single Six is awesome. I enjoy shooting it, it is accurate although maybe not quite as accurate as the S&W's, and it provides some nostalgia to the wildwest period of our country.
So choose the platform you like, single action or DA/SA. Either will serve you well.