By the looks of your Avatar, are you loading for hunting rounds?
If so, you shouldn't be worried about getting the last fraction of MOA out of your load development. You want maximum reliability and ease of feed into the chamber.
If on the other hand, this is for punching paper at long distances, you first develop a load that is insensitive to slight variations in charges (find a node), then adjust the seating depth if there is a noticeable change in accuracy as you get closer to the lands. If the jump distance isn't making a difference in accuracy, you're finished. The good thing is with a rifle cartridge, the percent change in MV is much less sensitive to seating depth than with a small case pistol cartridge so you may not have to go back and forth tweaking the charge weight, then the seat depth and back again to the charge weight.