The Titanium cylinders have poor extraction, especially at higher pressure. This is why Ruger opted not to use Titanium for the Super GP-100, but to lower the cylinder's mass by more aggressive fluting. The low rotational inertia is the real advantage of Titanium cylinders. It does reduce the weight of a carry gun, which is probably more significant for the 329PD than for a little j-frame. In either case, a heavy penalty is paid in felt recoil, not just for the Titanium cylinder, but also the scandium/aluminum alloy frame. On a heavier competition gun, it's the ability to accelerate and stop the cylinder faster and with less wear on the bolt and notches that make Titanium desirable, but the trade-off is poor extraction. Most of the time, the cases just stick when ejecting them. Sometimes I had the case heads separate. The cases would stick to the chamber walls and the pressure would cut the case when it blew the head against the recoil shield.
It should be fine with any kind of bullet so long as they're not lighter than the 120-grain minimum that S&W specifies. I would keep pressures low to avoid sticking cases.
Man that is a mess! 