I've been playing with slugs of all kinds beginning with Winchester and Remington rifled slugs out of my Ithaca Deerslayer back in the sixties. It was about a three incher at sixty yards. Brennekes didn't work with it but did with an Auto 5. I got a Lyman foster mould and the Lyman "rifling" swage for it and about duplicated the Win/Rem performance using the old card and fiber wads. When S&W got caught up in the Bangor-Punta thing they brought out the BRI slugs in S&W shells, two varieties, soft for choked barrels and hard for "police" use. Still only had smoothbore guns.
Fast forward to the rifled choke tubes. Mediocre success. Got a Hastings barrel for my 870, tried a bunch of sabot slugs. Started to believe in the 100-125 yard performance. Also got the Lee "Key Drive" mould and it was fine to 50, only slightly better than smoothbores and conventional slugs.
Now, having had Hastings, Remington and Mossberg rifled shotguns, I am shooting a Savage 12 ga Rifle....(210). Along the way, I've gotten the Lyman sabot moulds in 12 and 20 and had varying degrees of success. Better than rifled slugs out of smoothbores, not as good as the commercial slugs. Federal Truballs work great out of rifled and smoothbores.
My boys shoot Mossy rifled guns, 12 and 20, and shoot Lightfield Hybreds and have both made accurate kills on deer out to 110 yards. I'm finding that the Hornady SST, the Lightfields, the Federal Barnes Expanders and others will do right fine out to 150 if you can stand the punishment.
I had back surgery a couple years ago and am a little more sensitive to recoil.
LIghtfield came out with a managed recoil hybred which I shot Sunday. Three in an inch and a half at fifty yards, too much wind for a 100 test.
Some other slugs that have worked out of rifled barrels (against conventional wisdom advice) are Brennekes (they even recommend it), Nobel Strike Slugs and Truballs.
Bottom line, in my opinion, is that you have to experiment, you can go against CW, and you can shoot past 100 yards if you have a good gun/slug combination and the ability to do it. The drop is much like the 45-70, a lot of it. I've about given up on the Lyman "sabot" slugs but will play as time permits.