To sight in the revolver you should fire from a bench or other rested position. Check the rear notch of the sight and see if its close to being centered and if not move it to the center. This will be a good place to start. I usually set a target at 7 to 10 yds at first with a small dot to aim at. If shooting at a 25 yd timed and rapid Bullseye target I can see the “X” and use that at my point of aim at close range. One of those small orange stick on targets, about 1” diameter is also another good choice. For such a small target use the typical point of aim with the "x" or the dot sitting on top of the front sight post. Fire 2 or 3 rounds from a rested position, they should all be close together, perhaps an inch apart if there are no other issues with the pistols or ammos accuracy. After the initial grouping I usually make a sight adjustment and fire one to see where it hits. Once I get one where I want it to go I’ll fire a couple for group to make sure they’re all in there and then run the target out to 25 yds and adjust elevation again if needed.
Some other points:
Focus on the front sight and not the target.
Move the rear sight notch in the direction you want the bullets impact to change, IE if the bullets are grouping to the left side of the target move the rear sight to the right, if they're hitting low move the sight up.
When adjusting the rear sight move it 2 or 3 clicks at a time until you get down to fine tuning. When making adjustment in moving the sights, go one click beyond and then back one click. This takes the slack out of the sight movement.
One of the problems with adjustable sights is that some will use the adjustment in order to correct a shooting technique error. For example moving the sight up because they're pulling their shots low. Once the pistol is sighted from a rested position any change in impact when shooting free hand should be a shooter problem not a sight problem.