I'd say the rise/run of your treads and risers should be influenced by the hunter you're building this up for - it depends on the disability.
Generally speaking, 7"up/9"tread is comfortable, but you might want longer treads if there will be a pause on each step. Similarly, you could go 9" up, but then a kid or vertically-challenged person might have issues getting up there.
i think that 7.5"up and 10" over is comfortable as any household main-stair can get.
Consistency between steps is the important part.
/under-employed architect here