I've heard of Ruark's famous saying "use enough gun". I also know shot-placement is more important than bullet mass and power. It's a reality that if you wound an animal even in the vitals without killing it, it'll get a hyper-adrenaline rush and thenyou can blow a whole in it the size of your fist and it'll still have enough oxygen in it's brain to charge you. In theory you could fire a a pin-sized projectile into the brain or spine of an animal and that's all it'll take to drop that animal. So wouldn't a suped-up .22 with enough power for penetration be adequate and ideal(less recoil) for hunting the biggest and most dangerous game? If not why?