Energy is relative. Speed is probably a better indicator, as is the mass and MEPLAT of the round. The published energies of specific cartridges are not the end-all to the truth. A 110 gr .357 magnum has more "energy" than a 158 gr. using the same load. Why? mass x velocity squared. Speed has more of a bearing than does the mass according to the mathematical formula.
Speed also allows the bullet to do its work. We rely on sufficient speed to open that hollow point. Speed also generates a larger temporary wound channel (that liquid state mentioned earlier).
So, if you have a slow moving bullet of light weight, the wound channel will be shorter and narrower. A slow moving heavy bullet will penetrate better, but will only create a small wound channel. A fast moving light bullet will make a larger wound channel and possibly exit. A fast moving heavy bullet will cause a large wound channel and probably exit.
A larger wound channel creates more damage to the vitals. An exit wound allows more blood out and more air in.
The bullet size also matters. Larger bullets tend to create more damage. Bluntness rips, sharpness cuts.
If this was an easy question to answer, then we would not have such a variety of ammunition. Even the .45 acp comes in 165 gr to 230 gr (lighter/faster to heavier/slower), then with some being +P for even more speed. Handgun ammo is not developed with boat tails for long distances - it is developed to fulfill the variety of needs of the shooter. Everybody has a different opinion.
My opinion: expanding through and through is best. Faster bleed out and the faster bullet creates a larger wound channel.
One thing that we have not discussed is penetration of objects that may be on or in front of the BG.
Overall, if you can handle it, get a .357 mag or .44 mag or 10mm or 9/40/45 Auto +P. Maximum bullet weight for better penetration. You can mop up the mess later.
If you want to put all the energy in the target, then get a .380
or a .25