Personally, if Parker gets cert, my gut tells me we'll get a "win", the 2nd Amendment scholarship, even by liberal anti's who don't like their conclusions admitting it's an individual right is overwhelming. However, it will probably be a narrow ruling, that it's an individual right, but that "reasonable" restrictions are permitted.
Then both sides have standing to duke out what "reasonable" means, between single shot rifles kept at secure armories and gun clubs on one side, and pre-NFA '34 on the other, for the next 75 years until one side or another can find the "perfect storm" that allows us to drag the SCOTUS back into it, kicking and screaming.
One thing I'll note, looking at another "definitive" case by way of analogy, Roe V. Wade back in '73 did nothing to thwart the ardor of pro-life or pro-choice forces. And it's hard to say how much of the increase in abortion is solely from that decision, or how much the liberalization of social mores contributed etc. A Roe loss could have arguably left us with largely the same results we see today. Pro-choice forces could have fought harder at the state level, and the net result, especially in liberal states and liberal large urban areas, might still be the same today.
Similarly, a Parker loss could just as easily ignite the RKBA-supporting public into a fervor, and we'll keep fighting as we've had to for the past 75 years, taking our losses and gains legislatively, under attack from those who deny the individual rights interpretation. So from the standpoint that we now operate under a de-facto "Parker Loss" climate, one way of looking at it says we've got nothing to lose.