My .280 Remington with my handloads using a 160 grains Nosler Partition bullet. Usually I use a .338 Win. Mag., but have also had excellent performance from my .280 Rem.
Over the years, my cousin, recently deceased, killed 22 bull elk with his Win. 70 Featherweight .308 Win., using 180 grains factory ammo. He didn't have any problem, but he was an excellent shot, also.
FWIW.
L.W.