Mainecoon;
Seeing as how your main gun is going to be the .22-250, you'll want to take at the very least one more gun, and two is better. Here's why: If you hit a good town & start really poppin' the dogs it's very possible to erode the throat in your gun. It's far better to take a few shots with the .22-250 & switch off to something else while that gun cools.
Ideally, with the Remington as the main gun, you'd also have a .223 and either a good .22 or a .17HRM. You trade off maybe every ten shots with the .22-250, and 20-30 with the .223, & pop the close-ups with a .22. People don't know how many close-ups they never see because they're focused out at a hundred yards & beyond.
The idea isn't to shoot as fast as you can, it's to hit as many as you can. It's getting a lot harder to find a good town anymore, but it's still possible. When you do get one, it's a rush.
900F