The 22-250's stock in trade has always been high velocity & flat trajectory with light varmint bullets.
It went head to head with the 220 Swift when the Swifts factory load was a 46 grain bullet, thus the slow standard twist.
Even now, the fastest & flattest shooting varmint bullet will be the 50 or 55 grain load, which the 1/14 handles perfectly.
It will handle up to 63 grain semi-pointed bullets.
If you want to shoot heavier bullets, get a .243 or 25-06.
With a 22-250 63 grain, you can get about 3,500 FPS in the 22-250.
A .243 will shoot the same weight bullet 3,700.
A 25-06 will push an 87 grain at 3,500+.
If you get a 1/9, then the very light & fast varmint bullets will often blow up in mid air.
EDIT: gun guy PM'd me to say the orginial 220 Swift load used a 48 grain bullet, not a 46 as I incorrectly stated. I had a Senior Moment.
rc