I carry a 17 shot 9mm, and/or a 642. I have a Detective Special also, that only comes out to play, or for special occaisions.
The 642, I avoid shooting +P through. Not pleasant. The CZ-75 9mm with anything, and any of the .38 Specials I have (with standard pressure or target loads) I'll shoot till I'm bored or out of ammo. The Detective Special isn't too bad with +P, I can shoot that, but the gun isn't rated to live through too many of them without needing work, so I don't do that. Full size .38/.357, shoot the .38 +p rounds all day if I have them. Funner with the milder loads, especially my softball handloads, but it's not a problem to shoot the +p.
.357? I've shot a GP100 (4"), and a S&W model 19, six inch. Both of them were fun with the .38s. The GP100 was impressively accurate, very, very nice with the .38s. The .357, 125 grain softpoints were not that much fun. Painful after less than 20 rounds. Yes, painful. My right wrist is arthritic, so I have to baby it. Such is life. Model 19 was less painful, but then, I shot fewer rounds through it. I fired 3 rounds of PMC softpoints through an old model 29 once. I stopped because I didn't think it would be a good idea to shoot the other three. It was fun, accurate, destroyed the log and rock I shot, and it's tempting to get one and load milder handloads for it. Big booms. But I'm not going to shoot anymore full-power .44 magnums by choice.
.40 S&W, I had one. It was a decent gun, but it recoils more than the 9mm, slowing me down, without giving enough advantage to be worth the recoil and added ammo expense.
.45 ACP through a SIG P220, I decided I wasn't really having fun anymore after less than 50 rounds. The recoil was not nearly as pleasant as a steel framed 1911. I don't have one of either.
I stick with mild-recoiling pistols -- .22, .38, 9mm. If I need more power, I always say I'll take a rifle or a shotgun. I'm tempted to try the 10mm, but I kind of think it will depend on the gun as to whether I'll be able to handle it.