I don't want to rain on your parade, but you'd first better check your twist rate on your barrel.
My Rem. M700 has a 1/14" twist, and though it shoots near 1-hole groups (got 5 of them Wed. PM resighting in a new 6-24x scope) with 50-55gr bullets, with any but the 60gr Hornady and 63gr Sierra Semi-point, any bullet over 60grs keyholes all over the target. It even shoots 5" groups with the Hornady 55gr V-max. 60gr V-max wouldn't hit the target at 100yds. An attempt with the 65gr Sierra's gave 6" groups with 3 of 5 hitting target sideways and other 2 with noticeable yaw.
Sierra labels the box with a recommendation of 1/10" twist minimum... However, my Remington Mod-7 in .223 with 1/12" twist shoots them to ~1.5" 5-shot groups which is about what it shoots anything.... And it has taken nearly a dozen deer with as many shots..... Think .243 with a 100gr bullet......
Needless to say my Bushmaster AR15 Carbine @ 1/9" twist shoots them sub-moa, as many as you want to shoot through the same hole..... typical Sierra accuracy....
If you have an "atypical" .22-250 with a faster twist barrel, you'll be hard pressed to find a better bullet in the weight range for the intended purpose, but a 1/14" TYPICAL .22-250 probably won't give you good results. I was pleasantly suprised by my little M-7 because I didn't know about the 1/10 "disclaimer" that Sierra put on the box when I ordered my first box. Good thing my Remington Mod-7 can't read.........
With Varget I'd start with 29.0gr for about 3,000fps and 34.0gr MAX for about 3,450fps. I personally haven't been thrilled by Varget. I prefer RL15 and H380 for my .22-250. It shoots best with 38.0gr of H380 with a 60gr Hornady giving ~1/2" groups at 3,500fps..... Kills deer about like the .257WbyMag w/100gr bullets.... bullet are usually balled up under the hide on the far side w/65% weight retention.... ie: 35-38.5gr...
Maybe, just maybe your rifle will be the "exception"..... Only one way to find out. But expect the Varget loads with the 65gr GK to perform better closer to max, as that is where they'll be best stabilized... if they will at all....