If you are familiar with how to shoot your at 15 in a cqb environment, it is probably the single most effective tool you could use, but practice, take a carbine course etc
I have hornady 77g hpbt with a stout charge of 8208xbr. It should be clocking in around 2700fps+. At that speed it should fragment nicely, I have seen how it plays with a whitetail at 30yds, I don't want to be on the wrong end for sure.
Accept the fact that most suitable HD rounds and loads will over penetrate walls, know the background of the target, have a plan in your house
For example, I live in a 2 story house, if the kids/wife are upstairs and somebody wants to take my TV from down stairs, that really sucks,
If they come up stairs I have a safe room/Alamo area where I will stay, if bad dudes come down the hall, they have a really bad day.
In summary, your familiarity with the firearm and your forethought is more important imho than the load, but I like the 77g hp. I think it is a TAP load I attempted to copy