you'll probably see leading within ten rounds. But, you have to prepare for a meaningful way to evaluate the leading issue.
1. Shoot only one powder / bullet / primer combination at a time.
2. Do a load development set, and start with the lowest charge.
3. Shoot 5 rounds, and examine the barrel. With the faster powders (Bulleye, 231) look for leading at the leade as charges increase. Arguably, swab / clean the barrel between each test, etc. etc.
However, an alternative approach would be to simply shoot some proven recipe you like with this bullet. The issue may be the particular barrel and its rifling, rather than the recipe factors. (Personally, I am a believer in burnishing barrels with jacketed bullets, before I worry about sorting out lead loads.)
Jim H.