I'm a country boy. In my little version of SHTF (it's really a myth IMHO, but lord knows what the next 7 years has in store) food procurement is probably more important than killing people. To that end, I've stored (since the election) fishing stuff, some of it illegal, but legality would take a hike if I'm hungry. But, hunting will always be part of my life regardless of any odd scenarios. So, I stick with the heavies.
FWIW, I carry a 140 Speer JHP over 17 grains 2400 for self defense in this caliber. it hits hard. I shot an 80 lb pig in the head a while back using my 3" medium frame carry.. The bullet hit in his skull and the ballistic pressure from it popped his right eyeball out. It was a little grotesque, but illustrated the power of the caliber to me. In my mind, about any load in the caliber is fine for defense. I carry a lot less most of the time. If you're carrying a bullet that expands, don't sweat over the grain weight of the bullet. But, a big, flat point SWC will penetrate better and leave an impressive trail of tissue damage. I've seen this with my own eyes. From a rifle, it's VERY impressive.
So, I am swayed to the heavies for that reason. Virtually any magnum load will kill a human. Hogs are a little tougher target.