The manual of arms may be marginally simpler, the guts were never simpler and never will be.
Nonsense. I can strip an SP101 or Speed Six as fast as any 1911 by removing a single screw. But the fact is I almost never need to.
As far as reliability, I can count on two hands the number of times a wheelgun has failed me out of many many thousands of rounds and close on 75 platforms. Most all of the semis I've shot, including very nice Glocks, have had some level of jamming trouble even if only stovepipes or FTF from bad magazines. There's simply more that can go wrong with a semi.
Rim dropping below the extractor star. NEVER HAD IT HAPPEN
S&W extractor rod unscrewing itself. NEVER HAD IT HAPPEN
Bullet pulling forward under recoil, tying up the cylinder. HAPPENED ONCE WITH A TAURUS .45 Colt
Any little fiddly part, bolt/cylinder stop, hand, innumerable springs signing off. NOPE. I busted a Single Action Army replica's main spring once, but that's an ancient design using a strip of sheet metal. Coil springs last forever.
Screws backing out. NEVER HAD IT CAUSE A PROBLEM. It's only really an issue on some single actions.
Case binding on recoil shield. NEVER EVEN SEEN IT.
Timing issues. If this is bad enough to cause a jam, it's bad enough to notice long before you shoot it. I've only ever seen one or two very old Colts with timing so bad they would not even function.
Sprung crane. NEVER HAD IT HAPPEN
Crud under extractor. NEVER SEEN IT
Gunge build up on cylinder face. NEVER HAD IT CAUSE A JAM. I had barrel/cylinder gap binding on the same Taurus .45 mentioned above. That's it.
Your list left some issues off. I had a Security Six, rough side of Hell surplus, that would pierce primers with its hammer-mounted pin. Trip to Ruger cured it. I've had a few Nagant handloads seize in the chamber from overpressure when I was figuring out how to handload that weird round.
But as to Semis, the list of major and minor jams is real long. The only one that was pretty much flawless was the P225. Compare that to my main carry pieces--a Detective Special and a Speed Six. Out of thousands of drill rounds of all conceivable types of ammo from shotshells to 200 grain bear loads NEITHER HAS EVER JAMMED, BEEN STUCK, OR FAILED TO FIRE. ZERO PERCENT FAILURE. And one of those dates to the 80's while the other is half a century old. No semi can beat that without religious upkeep and top quality ammo. Even a high end 1911 will choke if fed ratty Russian steel cased crud. My wheelguns LAUGH at that ammo. LAUGH! HA! I can shoot them
UPSIDE DOWN
WITH MY HEAD
IN A BUCKET
OF PIRANHA FISH!
But beyond this many of us find we can conceal, draw, aim and fire a wheelgun better than a semi. For close range defensive firepower they're still perfectly fine. I wouldn't advise using them for offensive work, but then I wouldn't advise going on the offensive with some foolish high cap either. That's rifle work.