In my experience, Hornady exhibits some of the worst setback of any mass produced ammo out there. I compared it to Speer and Federal HST ammo in a repeated chambering experiment. After 20 rechambers, the Hornady showed more setback than the Speer, and the HSTs were the best. As in little if any setback on the HSTs. That's one comparison so take it for what it is, a very small sample size. In some testing with my chronograph, I also found Hornady ammo to have the most exaggerated velocity numbers when comparing similar barrel lengths. HSTs were the most consistent.
Again, small samples, and not statistically relevant, but for me it was enough that I have stopped buying Hornady ammo. I also feel their bullet tech is not as good as Speer's bonded, or Federal HST nonbonded build.
So first and foremost, I recommend changing ammo brand.
More importantly, and germane to your question, I suggest not repeatedly chambering a round. Just train to chamber a round as quickly as possible in a defense encounter. I know it isn't ideal, but if I was going to carry a magazine into my work environment every day, I would be concerned about setback as well. If I insisted on keeping it chambered, I would likely just plan on rotating a new top round into the gun frequently if my ammo showed any setback.
The other option is to switch to a gun model that allows for dropping a round into the chamber from the ejection port and closing the chamber, without damaging the extractor. My Beretta 92 explicitly said in the manual that the 92 was one of the few designs out there that allowed for this. You may solve your problem that way.
Another suggestion if it wasn't already made is to buy Ammo Armor sleeves for your magazines.
https://ammo-armor.com/