You didn't mention the barrel length... that can make a difference. I'm assuming 5"+, but I know there are some shorties out there.
I agree with the other poster... if you are already at max load, you need to find a better solution; save your nice pistol. FWIW... I had this problem in 9mm, using BE-86. I reached a threshold where more powder didn't translate to more velocity, not in my shorter barreled Kahr. It was dumping unburnt (underburnt?) powder on my hand, even. It was just the weird combination of bullet/powder/barrel... Unique, which has a similar burn rate (and characteristic..) never did that.
There is one other facet... the pistol. My experience with Ruger single-actions tells me to check the cylinder throats for uniformity... you may have a big throat that isn't the right size, or the cylinder is not even... leaving a bigger gap at one cylinder position than at it's 6 O'clock.