Yes and no
For a 30-30, 270, 06, 308 ect ect no not at all
But for a 223, 22-250, 243, 7.62x39 or 6.8 you bet they do!
ding, ding, ding...Best answer...
Use enough gun and you don't need no stinkin' Barnes.
I shoot a 100 grain Sierra Game King in .257 Roberts and it does a great job on deer. It's a bit light for large hogs, but it knocks down anything I'd wanna eat. I shoot Game Kings, 150 grain, in 7mm Rem Mag. Great bullet for long range out west, BC of .535. I shoot Nosler BTs in .308 and .30-30 (Contender Pistol) and they're deadly on deer or hogs in either gun. I'd worked a load up with Barnes 140s, but I've been quite impressed since then with 150 Nosler BTs on hogs and deer, great penetration and expansion. Sorta makes the penetration problems I've read about them seem like myth. I trust 'em fine.
As for Core-Lokts, they've been around for a long time, work fine in cheap factory ammo if you don't handload. But, I prefer what I shoot to them. They've never impressed me for accuracy. I handload so that I can shrink my 100 yard groups to under 1MOA. It ain't that the bullet kills any quicker, but I'm more confident I can hit with it, especially in West Texas or New Mexico where I might be on the far edge of my 400 yard self imposed limit. If you never get out of the woods, boring, but if you never get out of the woods, you don't need such demanding accuracy standards. I really don't "NEED" it where I hunt now mostly, but hell, I've got a fetish for accuracy in a rifle and handloading helps this fetish a lot.
Oh, 7.62x39, hell, I don't need no stinkin' high priced bullets. I've used the now extinct 135 Sierra Pro Hunter (.308 caliber) in the woods successfully, but I get better accuracy out of cheap Wolf 154 grain soft point and they're cheap. At woods ranges, they work, though I'll never brag about 2.5 MOA. ROFL It's a truck gun, knock about, not a hunting rifle for me. But, I took the scope off it and it's a beat around gun now, sort of a semi auto .30-30 utility rifle. It'll take anything the .30-30 will to 150 yards.