As far as frame wear, I am most concerned for the rails. The matte slide finish of the extremely hard nitriding extends into the rails, right in contact with the thin anodizing.
I guess I do not understand your concern on the aluminum frame rails in contact with the steel slide.
this arrangement is not unique in the gun world. Guns I own that have aluminum frames include Beretta M84 and M96 (40 S&W cousin of the M92), Sig P238, M1911 Commander and the Remington R51.
The AR-15's bolt rides on aluminum guides in the upper.
There are many other aluminum frame.steel slide guns in production.
My Beretta M84 has somewhere between 3000 and 4000 rounds through it and except for polishing the frame rails removing the color, there is no noticeable wear in the frame rails.
Keep the frame rails well lubricated and the risk of galling and wear from sliding will be greatly reduced if not eliminated.
I will agree that the life of an aluminum frame gun will not be as long as a steel frame gun, but it is still a long life.
Now, there are other issues with an aluminum frame that only time will tell with the R51.
On my Beretta M84, where the slide hits the frame under recoil the frame is peened over. Short term, it makes disassembly difficult as the channel for the guide rod has been reduced in size. long term, I suspect there could be a catastrophic failure of the dust cover at the front of the slide. But again, remember, i have in excess of 3000 rounds through this pistol.
So, with the R51, i would pay attention to the step that stops the bolt under recoil. This is where I might anticipate a problem if one will happen as the slide drives the bolt into this stop with each firing.