I should be ASKING the guy who has been doing this for 40 years this question, not ANSWERING it.
I use Lee dies for my father's and grandfather's old hunting rifles I inherited. I don't plan on doing anything fancy with them. (At this time.) So, straight out-of-the-book recipes, no tweaking, the Lee Dies do exactly what they are supposed to do. I started with 22-250 on RCBS dies, 38 grains of H380 under a hornady 55 grain bullet, and whaddaya know, it worked......exactly like it's supposed to. 1/2" groups.
Now I am about to start reloading for ARs in 5.56 and .243, and I will get small-base dies to start with since they are for autoloaders. I want to stretch the .243 out to some long distance, so I may get a high-end seating die, like a Forster. But that's after I have decided that conventional dies aren't good enough. (I may not even hit that level.)