Howdy
Take a look at this photo.
On the left is the cylinder from a Stainless 'original model' Vaquero chambered for 45 Colt. In the middle is a cylinder from a New Vaquero chambered for 45 Colt. On the right is a 2nd Gen Colt Single Action Army cylinder, also chambered for 45 Colt. Notice how much more metal there is between chambers with the stainless 'original model' Vaquero cylinder than the other two. The stainless cylinder can take much more powerful ammunition than the other two.
Do you have a caliper?
If so, take out your cylinder and make some measurements. The cylinder will tell you what ammunition it is capable of firing.
This question gets asked so often that I took some measurements and wrote down the results.
Ruger Blackhawk----------------------- Length 1.700, Diameter 1.726, Distance Between Chambers: .060
Ruger 'original model' Vaquero-------Length 1.701, Diameter 1.728, Distance Between Chambers: .060
Ruger New Vaquero-------------------- Length 1.610, Diameter 1.673, Distance Between Chambers: .042
Colt Single Action Army 2nd Gen----Length 1.608, Diameter 1.652, Distance Between Chambers: .045
Uberti Cattleman------------------------- Length 1.618, Diameter 1.672, Distance Between Chambers: .043
The Blackhawk and 'original model' Vaquero cylinders are so similar in size, easily within manufacturing tolerances, that they can be considered the same size.
The bottom line is, if there is .060 between chambers at their narrowest point, you can shoot +P 45 Colt ammunition in it.
If there is only around .042 or so between chambers, you cannot do so safely.