Another AA 2400???

My limited experience suggests 2400 is a little cleaner when reduced, while 4227 is a bit better in rifle cartridges like the 22 Hornet.

Overall, I consider their performance more similar than different in most applications.

I went with 2400 for my cast rifle loads because it was cheaper but I know people who swear by 4227 for the same applications. I’ve not used it personally

For handgun use, no doubt, 2400 is the best.

That's a good question. I use both for different things. They are not completely interchangeable but their uses are real similar. Close enough they're almost interchangeable. Both are good magnum handgun powders and both are good low-pressure rifle powders. 4227 burns a little slower but 2400 burns a little cleaner, in my experience. Anything you want to do with 2400 you can probably do with 4227 at lower pressure and maybe a little better. It depends on what you're loading and what for. I load .44-40WCF hunting rifle loads with 4227 to keep the pressure down in older '92 Winchesters without losing velocity. But, I use 2400 in my Uberti/Remington 1895 knock-off for .44-40WCF hunting handgun loads because it seems to work better in the shorter barrel without running up the pressure too bad. The loads are safe in and work fine in either gun but the 2400 is better in the handgun loads and the 4227 is better in the rifle loads. It's real close. I guess the big thing is, you need some barrel to make the most of 4227 vs. 2400 - but 4227 performs almost as well with a shorter barrel and at less pressure.

Keyfer 55 said:

I'm leaning towards 2400. I have used it in
heavy 20 ga shotgun loads to . It meters better.

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If you can find it, 2400 is a good powder to have in the stable, no doubt about it. IMR 4227 is a little less known and less popular so it can be a little easier to find.

2400 is more versatile. It is also, on average, more accurate in the old standard magnums.