Here's someone from over on the Colt forum who wasn't as lucky as the OP:
"So....let me begin by saying I’m not a newbie, I’ve been shooting for over 30 years, especially revolvers. I was excited to receive a new Colt Python 4.25. Fit and finish looked perfect, with the smooth trigger that felt like greased ball bearings, no stacking. I couldn’t wait to shoot it, boy did that enthusiasm turn to misery today.
First six rounds of full house magnums, a little more recoil than I expected but within reasonability. My next six rounds I adjusted my hold and aim, much better results on the target. My third six rounds started the problem...it was very hard to push the cylinder back in. These are factory rounds, not reloads. I managed to get the cylinder in, touched off the first round double action, VERY stiff trigger pull, it goes bang. Second round, I can’t pull the trigger hard enough to rotate the cylinder. It seemed to get a little easier to get the loaded cylinder in after the gun cooled off. It did this half a dozen times and I said “no mas”, back to the Colt Mothership...or CZ...or whatever it is now. Meanwhile, my 1959 Colt Single Action in .44 Special ran like a top with two inch groups at 10 yards....with my 56 year old eyes! They clearly don’t make em like they used to....
I looked over the pistol for an easy fix, lubricated at the range, no dice. It looks like a trip back to Hartford and goodness only knows when I see it again. Anyone have any quick fix guesses?"
I'll pass.
BTW, my last lemon Colt was back at Hartford basically from 8/20 to 4/21.