Hi...
Mr preferred .45Colt load is a commercial cast coated 255gr LSWC over 8.0gr of Unique.
Shoots quite accurately in a variety of handguns and my Uberti .45Colt lever action rifle.
Handguns are a pair of original full size Vaqueros, a BlackHawk, S&W 25, a Uberti nickel SAA clone, a Uberti Remington1875 clone and a Uberti Schofield clone.
I don't shoot that load in my Contender or my SBH Hunter in .45Colt. I reserve those guns for heavy hunting loads using jacketed bullets.