The diameter , weight, and speed of the bullet all play a part in the physics. You change one of these and there is a consequence to the others. With a smaller diameter bullet, you generally have a faster twist and faster Mv. In the same cartridge, heavier bullets definitely benefit from faster twist.
For example, all of my Ar's are either 1/7, 1/8, or 1/9. They all shoot 55 to 77gr bullets just fine, but the 1/9 will shoot the lighter bullets better and does fine down to 45gr. The 1/7 will shoot the 77gr better, but not so good with a 45gr. 22-250 is the same exact diameter bullet, but with its 1/12 twist, it will not shoot anything over 62gr or the bullets tumble, it generally uses 35gr to 55gr bullets.
The 22-250 has a much larger case volume than .223 and theoretically should be able to shoot a heavier bullet , but they crippled it with the twist rate.