Depends on your definition of reliable
If you take say, a new semi-auto pistol, and right out of the box it fires several times without a malfunction. You take it to the local range and shoot a box of ammo without a failure. Does that mean it's reliable? That depends.
Now, take your new semi-auto to an IPSC match, shooting bursts of rapid fire, up to 30 or more rounds in just a few seconds. Get that gun hot hot hot. Be the last one to shoot on a stage and the first one to shoot on the next stage. Shoot 30 more rounds as fast as you can. It's 95 degrees outside. Shoot all six stages without a malfunction. Do this at three or four matches without a malfunction, 200 rounds per match. NOW your pistol is reliable right out of the box.
It's not uncommon that a new gun will experience a few malfunctions during those first 1000 rounds or so that you never see again. Even if there are no malfunctions, the slide will work faster or at least more smoothly as the gun breaks in, allowing one to improve their split times.
So, there's breaking in and there's breaking in...depends on how hard you're using the gun.