I too am a member of the High Horsepower club!
I generally carry a Beretta 92FS in a fanny pack.
My boss introduced me to this style of concealment. At first, I thought it to be a bit silly, but after trying just about everything else, I found it to be the best way to carry.
I don't care what people think or say as I am protecting myself and my family. My daughter calls it my "murse" (man-purse). I usually wear it around my waist, but for quick trips to the grocery store, etc, I have been know to carry it like a purse. I bought a big enough one that holds my wallet and my blackberry.
I carry in my car when I travel to different job sites for work, but generally do not carry into the job site since most strongly discourage it, and I generally feel safe once I arrive. I find the fanny pack a convenient way to carry my weapon from the house to the car, etc. If I stop off say at Walmart or a parts house, I simply sling the fanny pack over my shoulder....
If I am forced, and I do mean forced to dress up, I use a Fobus belt holster which a wear slightly rearward of my right hip. I have found this to work very well, but you then cannot take off your sport coat until you are safely back in your own domain.
I also carry a Bersa Thunder 380CC on a belt holster. If I can wear my shirt untucked (which as a big guy I do 90% of the time), I use a left handed holster and place it in the small of my back on the right side. I found that easier when reaching behind to turn my palm towards my back to retrieve the weapon. It rides and hides welll carrying that way and is not bad even when seated or driving, though it is rather difficult to retrieve while strapped into the car, but I usually have my fanny pack laying on the seat next to me while driving.
I hope this helps.