There are two schools of thought...both valid.
One is that the magazine is designed to function, no matter how many rounds are in it. Like the gun...it's a machine. It was designed to function. If it's correctly built, it will function. It doesn't have a choice.
The counterpoint:
The two most likely places to have a misfeed: On the top round, due to maximum spring tension...and on the last round due to minumum spring tension. This is mainly a function of operating at the two extremes of the design. The law of averages also comes into play.
To address the first extreme, many people load the magazine to capacity...chamber the top round...engage the safety if applicable, and go about their business. The time to have that first misfeed is before the fight starts...not after. I'm one of those.
To address the second, we install extra-power magazine springs, and hope that we can solve the problem before we get to the last round...which the law of averages says that we likely will.
Statistics have shown that the average deadly encounter inolving firearms on both sides are settled within 3-5 seconds, with a total of 3-5 rounds expended. Total...for both combatants.
This applies, no matter how reliable the gun/magazine/ammunition combination has been on the range.