As far as loads for the DE 44, there really isn't a lot to fiddle around with, unlike a lot of other calibers. This gun is pretty much bred to run on full power ammo or just slightly downloaded, so reduced loads are pretty much out of the question. (Plus reduced loads of 296 are bad ju-ju anyway.) In addition, the powder du jour for this gun is 296/H110, and in case you don't know, 296 and H110 ARE the same powder. They just come in differently labeled containers. The important point is that a 4 lb. jug of 296 is significantly cheaper ($10) than a 4 pound jug of H110, provided you could even find H110 in 4 lb. quantities.
The Lyman #49 manual lists a very narrow powder range of 23.0 min to 24.0 max with 240 grain JHP bullets, (reflective of staying away from reduced loads), and you use large magnum pistol primers with 296/H110. You should be roll crimping the case mouth into the bullet cannelure at least 5 mils, and that's about all there is to it.
Like I said, not a lot of room for experimentation with this gun, but it's a lot of fun to shoot, and after you get used to it you can shoot a 45 ACP and it will feel like a .380.
The DE unfortunately has a habit of kicking those hot empties back into your face, so wear safety glasses and a hat!!