HST in 147, grab a couple of boxes of +P to try them side by side if you like.
I'd also be perfectly fine with fourth-gen Ranger-T in 147followed by pretty much any HST, Ranger-T, Gold Dot, Golden Saber, or PDX1 load in 124+P or heavier.
I think it says something that one of Winchester's well known ammo guys keeps putting out a letter when asked about defense ammo, especially in short barreled pistols, highly recommending 147 grain bullets.
And I like to pick a good bullet design, because it's a mechanical process going on, and a well designed bullet will be more consistent through any level of clothing or tissue encountered.