The tang safety is the less ergonomic of the two. (ever try to manipulate a tang safety when using a pistol grip?)
Pistol grips are for pistols, absolutely worthless on a shotgun.
I shoot lefty. The Mossberg works much better for me. I have tang safeties on my doubles, too. I have a Winchester autoloader for which I had a left hand crossbolt safety installed, but at least the safety is IN FRONT of the trigger guard on that gun and out of the way when shooting if left with a right handed configuration. Remington loves to put the safety to the rear of the trigger guard. I've inadvertently clicked the safety on several times on my 597 magnum, irritating. My fingers ain't THAT fat, either.
Regards to fit, number one with me. It also reduces felt recoil to properly shim/fit the gun. Helps it point naturally, important on those low, fast teal or close in doves and, of course, flushing birds. It's easy to fit a pump with shims. Mossberg knows this and even offers a shim kit, but I shimmed both of mine with coke bottle plastic, works like a champ.
I have a new to me 535 with 3.5" chamber. I've got to pattern it to see if it's going to pattern good enough to suit me with steel T shot. It'll have to go some to get the 90+ percent patterns I get out of my 10 gauge H&R, though. Yeah, I can see myself trying to shoot geese with 3.5" steel T shot and a friggin' pistol grip.
My home defense shotgun is a Remington.........Spartan 20 gauge coach gun. Of course, it's only branded "Remington". It's the only Remington shotgun I've ever owned with a tang safety. It's also my go to dove getter. It's very short WITH a full butt stock and shoots where I look.
I could live with a 870 as a home defense gun, just remove or disable the safety and keep it unloaded. Maybe I could super glue the safety off. That way, when I chucked a round into it, and shouldered it, I wouldn't turn the safety on as I reached for the trigger.
Of course, I only shoot lefty due to an eye dominance problem. If I had a pistol grip on it and shot it like the rifleman did his 92 from the hip, hell, I could live with that safety, couldn't HIT anything, but I could live with the safety and just hope the noise and muzzle flash scared him off. I'd rather use my 20, though, quick and I'm quite deadly with it. Humans are a lot slower and bigger than doves and 3 buck is pretty evil.