I'm wondering whether this is a three-strikes and you're out kinda problem with this particular situation. First strike: a new Ruger 10-22 barrel. Some I've experienced in the past few years have been very rough inside, at least for the first thousand rounds. My B-I-L bought a stainless Wal-Mart 10-22 and I could not get that rifle to shoot, no matter what "magic" I could do for it...until we got a Green Mountain barrel. Then groups shrank from 1 1/2" to 5/8" at 50 yards!!!
Strike Two: Rem Thunderbolts. They're about the worst quality rimfire ammo I've found in over 50 years of shooting. Numerous misfires, noticeable variations in pressure/velocity, dirty shooting. Most knowledgeable shooters shunned them years ago.
Strike Three: Being a semi-auto and a new rifle bore, firing lots of rounds in a hurry, barrel overheating and it's attendent effect on wax-coated bullets was the worst thing to do. If that happened...you're OUT!!!
That was the worst leading I've ever seen in a .22LR, even from old, pitted bores.