A 1-14" twist centerfire on the other hand is a one trick pony. Light fragile bullets at short to medium range.
What do you consider "medium range"? Furthest
measured distance at which I've popped a praire dog with a 1:14" .220 was 782 yards. Many, many more have fallen to that rifle in the 400-600 range. That's with 55 gr. moly V-max @ 3,850. The rifle prints 10 shot .72 MOA 200 yard groups with that load.
Think a factory .22-250 with a 1:9 twist and 75+ gr bullets can do much better?
As well, if someone were that serious about making itty bitty long range groups with a .22 centerfire, all the advantages of the .22-250 (more rifle options, factory 1:9 rifles, more/cheaper factory ammo) are kaput anyway. Dude's gonna be using a custom barrel and hand loads.
Me? For accuracy work at ranges exceeding 500 yards, I'm not using any .224 cal. Far better choices in 6mm, 6.5mm, 7mm and .30 cal.
22 centerfires today are the dual purpose round for lots of folks that 243 was 20years ago.
I just don't see that. For one, a lot of states do not allow medium/big game hunting with <.244 cal. And in terms of sales, the only .224" cartridge that exceeds .243 win is the .223; there's an obvious reason for that.
More to the point, anyone doing accuracy work with .22 centerfires is either playing with .223 (typically in an AR), or they've moved into .22 BR or .22 PPC. Nobody who is serious about it is using the .22-250, .220 Swift or any of the other cartridges that are and always have been varmint rounds. I don't recall hearing of any matches won or accuracy records set with a .22-250.
Both are varmint/predator cartridges. That's what they were designed for, what they have spent decades on end being primarily used for, and it's what most of the factory rifles are tailored to. The 40XB is about the only precision target rifle I know of that comes in .22-250. But then, it can also be had in .220 Swift......