Years ago I loaded the Speer 60gr FMJ using the reduced data in their manual for my 243. The object was a light load that hit close to the same POI as my regular load for picking off similar critters. I have to say it was a hoot to use, not overly loud, but a bit more than a .22 might be. It worked well for a dozen or so fox squirrels I had making a mess out of my feeders, but for a coyote you had to go for the head or track them further than I felt was reasonable.
For the cast loads you might do a search for C.E.Harris articles. He has been there done that with cast loads for many rifles and handguns. If you can't find something in his writings your probably not going too.