My tactical competition rifle is a 243. It has a 7.5" twist barrel, to shoot heavy bullets. My best group is .24" though if I don't pull any shots I usually get 3/8" groups. Load is 44.0gr H4831SC, Sierra 107 SMK, in Lapua brass. Above book max...
Upside is light recoil, and really good downrange performance with both drop and wind drift. The combination is hard to beat, makes for fast follow-up shots, and the ability to spot your own hits. Even better if you put a brake on it.
Downside is that the barrels usually only last about 1800 rounds. One of the guys in my club shot a much heavier load than me, and his barrel went out at 1000 rounds.
A minor downside is that spotting the hits on F class 1000 yard targets is more difficult because the holes are so small. I got a couple misses called before the spotters found my holes. Was nice to see my wind corrections at almost half that of a 308.
I just passed 1000 rounds through my current barrel last weekend, and like everyone else I know running 243's, have to chase the lands with my load to keep the velocity up, I'm loading .050 longer than when it was new. Last weekend's shooting showed I lost 60fps from my last velocity check 250 rounds ago. My club has a group buy getting started on barrels, I like the cartridge, and will stick with it for a while, so I'm going to get 2 more barrels to have on hand. Barrels to a 243 are like tires to an indy car. Disposable and short lived.
Having said all that, if I were to start over I would run a .260rem or other 6.5mm bore cartridge. Is almost the same in drop and drift, slightly higher recoil which can be fixed with a brake, and barrel life tends to run in the 3500 round range, which means much less chasing the loads.