People are way too caliber obsessed in my opinion. If you like the CZ550 FS then get a 6.5x55 or a 7x57. If you like the Weatherby Vanguard S2 then get the 6.5 Creedmoor. If you like the x-bolt Micro Midas then choose between the 243 and 7mm-08, because it's not offered in a 6.5 variety. In a case like the OP's, choosing a caliber before the rifle makes zero sense to me. Find what rifle fits you and turns you on, and then worry about caliber.
Is there a difference between the calibers I listed? Sure, about 10-30% in terms of energy and cross-sectional area. If a 6.5 isn't available in your favorite rifle, and the 6.5 caliber is marginal for the game/conditions/range you hunt, then move up. If a 6.5 caliber isn't marginal for the game/conditions/range you hunt, then consider moving down. Don't make life tougher than it is.
As far as personal experience, I haven't noticed a difference in killing power between 223 through 30-06 as long as I use them within their limits (say 100 yards for the 223 on whitetail deer). I've shot multiple deer within 100 yards using both calibers (along with many other calibers in between), and it seems to work out the same every time; if I hit the shoulder they drop on the spot, if I hit the lungs they run 50-100 yards and then die. I wouldn't use the 223 on elk or try to shoot a deer at 200 yards, but within its range it seems to have the same killing power as everything else (I do plan to buy a 375 Ruger eventually, which will allow me to gather some data at a higher energy range). The data seem to support this, researchers found no significant difference in killing success or distance traveled as a function of caliber (all ranges were reasonable for the calibers used).
http://www.dnr.sc.gov/wildlife/deer/articlegad.html
I'm not liimited on the type of shots I can take with the 223 either, just the range. The last deer I shot with a Barnes TSX, as it was quartering towards me, the bullet took out one lung, clipped the liver, and went far enough to bust the stomach open. I guess it I was using my 06 I could have continued into the intestines and maybe exited through the ham